Genetic analysis of human H2N2 and early H3N2 influenza viruses, 1957-1972: evidence for genetic divergence and multiple reassortment events.
Identifieur interne : 000120 ( 1968/Analysis ); précédent : 000119; suivant : 000121Genetic analysis of human H2N2 and early H3N2 influenza viruses, 1957-1972: evidence for genetic divergence and multiple reassortment events.
Auteurs : Stephen E. Lindstrom [États-Unis] ; Nancy J. Cox ; Alexander KlimovSource :
- Virology [ 0042-6822 ] ; 2004.
Descripteurs français
- KwdFr :
- Alignement de séquences, Données de séquences moléculaires, Grippe humaine (virologie), Gènes viraux (génétique), Humains, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Séquence d'acides aminés, Variation génétique, Virus de la grippe A (génétique), Virus recombinants (génétique), Évolution biologique.
- MESH :
- génétique : Gènes viraux, Virus de la grippe A, Virus recombinants.
- virologie : Grippe humaine.
- Alignement de séquences, Données de séquences moléculaires, Humains, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Séquence d'acides aminés, Variation génétique, Évolution biologique.
English descriptors
- KwdEn :
- MESH :
Abstract
Phylogenic analysis of all gene segments of human H2N2 viruses isolated from 1957 to 1968 was undertaken to better understand the evolution of this virus subtype. Human H3N2 viruses isolated from 1968 to 1972 were also examined to investigate genetic events associated with their emergence in humans and to identify the putative H2N2 ancestral virus. All gene segments of human H2N2 viruses demonstrated divergent evolution into two distinct clades (I and II) among late H2N2 isolates. All gene segments of 1968 H3N2 viruses that were retained from human H2N2 viruses were most similar to clade I H2N2 genes. However, genes of both clades were found among H3N2 isolates of 1969-1971. Unique phylogenic topologies reflected multiple reassortment events among late H2N2 or H3N2 viruses that resulted in a variety of different genome constellations. These results suggest that H2N2 viruses continued to circulate after 1968 and that establishment of H3N2 viruses in humans was associated with multiple reassortment events that contributed to their genetic diversity.
DOI: 10.1016/j.virol.2004.06.009
PubMed: 15380362
Affiliations:
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pubmed:15380362Le document en format XML
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Lindstrom</name><affiliation wicri:level="1"><nlm:affiliation>Influenza Branch, MS-G16, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. slindstrom@cdc.gov</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Branch, MS-G16, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333</wicri:regionArea><wicri:noRegion>GA 30333</wicri:noRegion></affiliation></author><author><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J" last="Cox">Nancy J. 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Lindstrom</name><affiliation wicri:level="1"><nlm:affiliation>Influenza Branch, MS-G16, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. slindstrom@cdc.gov</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Branch, MS-G16, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333</wicri:regionArea><wicri:noRegion>GA 30333</wicri:noRegion></affiliation></author><author><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J" last="Cox">Nancy J. Cox</name></author><author><name sortKey="Klimov, Alexander" sort="Klimov, Alexander" uniqKey="Klimov A" first="Alexander" last="Klimov">Alexander Klimov</name></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Biological Evolution</term><term>Genes, Viral (genetics)</term><term>Genetic Variation</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A virus (genetics)</term><term>Influenza, Human (virology)</term><term>Molecular Sequence Data</term><term>Reassortant Viruses (genetics)</term><term>Sequence Alignment</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term><term>Données de séquences moléculaires</term><term>Grippe humaine (virologie)</term><term>Gènes viraux (génétique)</term><term>Humains</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Séquence d'acides aminés</term><term>Variation génétique</term><term>Virus de la grippe A (génétique)</term><term>Virus recombinants (génétique)</term><term>Évolution biologique</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genes, Viral</term><term>Influenza A virus</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Gènes viraux</term><term>Virus de la grippe A</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Biological Evolution</term><term>Genetic Variation</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Molecular Sequence Data</term><term>Sequence Alignment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Séquence d'acides aminés</term><term>Variation génétique</term><term>Évolution biologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Phylogenic analysis of all gene segments of human H2N2 viruses isolated from 1957 to 1968 was undertaken to better understand the evolution of this virus subtype. Human H3N2 viruses isolated from 1968 to 1972 were also examined to investigate genetic events associated with their emergence in humans and to identify the putative H2N2 ancestral virus. All gene segments of human H2N2 viruses demonstrated divergent evolution into two distinct clades (I and II) among late H2N2 isolates. All gene segments of 1968 H3N2 viruses that were retained from human H2N2 viruses were most similar to clade I H2N2 genes. However, genes of both clades were found among H3N2 isolates of 1969-1971. Unique phylogenic topologies reflected multiple reassortment events among late H2N2 or H3N2 viruses that resulted in a variety of different genome constellations. These results suggest that H2N2 viruses continued to circulate after 1968 and that establishment of H3N2 viruses in humans was associated with multiple reassortment events that contributed to their genetic diversity.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J" last="Cox">Nancy J. Cox</name><name sortKey="Klimov, Alexander" sort="Klimov, Alexander" uniqKey="Klimov A" first="Alexander" last="Klimov">Alexander Klimov</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Lindstrom, Stephen E" sort="Lindstrom, Stephen E" uniqKey="Lindstrom S" first="Stephen E" last="Lindstrom">Stephen E. Lindstrom</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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